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Those with symptomatic disease should discuss surgical options with their physician before starting GLP-1 therapy

But that doesnt mean its safe to do so, even if the medication looks clear

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First, if the body is still making sufficient insulin, the insulin cannot work efficiently due to a condition called insulin resistance

Recent studies have also demonstrated that exendin-4 is mediated by Ca 2+ /calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/prolactin regulatory element binding (CaMKK/CaMKIV/PREB) pathway increases liver ABCA1 expression and reduces cholesterol accumulation [71]

The answer follows a strict safety rule known as the 28-day guideline